5/7/2023 0 Comments Troga etymology![]() The micro-quantities required vary according to the age, sex, physiological state, and physical activity of the individual, with an increased demand during the growth phase, gestation, lactation, intense stress conditions, and the occurrence of certain diseases 2.Ĭommonly, vitamins are classified as liposoluble and water soluble according to their physiological and physicochemical properties in common 1. Vitamins are essential micronutrients found in small amounts in food and are indispensable to the human organism 1. Palabras clave: Filoquinona Fuentes Índice Internacional Normalizado Interacción fármaco-alimento Warfarina El objetivo de este estudio fue recopilar información sobre la interacción de los medicamentos de la warfarina con la vitamina K y con los suplementos dietéticos y otros alimentos. Además, otros alimentos pueden interactuar con la warfarina, a pesar de su contenido de vitamina K. Sin embargo, se sabe que una ingesta muy baja y/o fluctuaciones en la ingesta de vitamina K son tan dañinas como un consumo alto. Desde el inicio de la terapia, es necesario que los pacientes realicen el monitoreo a través del tiempo de protrombina y la proporción normalizada internacional. Entre los muchos anticoagulantes disponibles destaca la warfarina, un antagonista de la vitamina K, que ejerce sus efectos anticoagulantes al inhibir la síntesis de la vitamina K 1 y la vitamina KH 2. La función principal de la vitamina K es actuar como un cofactor enzimático para la síntesis de protrombina hepática, factores de coagulación de la sangre y proteínas anticoagulantes. La ingesta adecuada de vitamina K es de 90 y 120 μg/día para hombres y mujeres adultos mayores, respectivamente. La vitamina K se encuentra en concentraciones más altas en plantas de color verde oscuro y en aceites vegetales. Key words: Drug-food interaction International Normalized Ratio Phylloquinone Sources Warfarin The aim of this study was to gather information on the drug interaction of warfarin with vitamin K and with dietary supplements and other foods. In addition, other foods can interact with warfarin, despite their content of vitamin K. However, it is known that very low intake and/or fluctuations in vitamin K intake are as harmful as high consumption. From the beginning of the therapy it is necessary that the patients carry out the monitoring through the prothrombin time and the international normalized ratio. Prominent among the many available anticoagulants is warfarin, an antagonist of vitamin K, which exerts its anticoagulant effects by inhibiting the synthesis of vitamin K 1 and vitamin KH 2. The main function of vitamin K is to act as an enzymatic cofactor for hepatic prothrombin synthesis, blood coagulation factors, and anticoagulant proteins. The adequate intake of vitamin K is 90 and 120μg/day for adult elderly men and women, respectively. Vitamin K is found in higher concentrations in dark green plant and in vegetable oils. ![]()
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